Fibronectin-Induced Proliferation in Thyroid Cells Is Mediated by v 3 Integrin through Ras/Raf-1/MEK/ERK and Calcium/CaMKII Signals
نویسندگان
چکیده
Departments of Biologia e Patologia Cellulare e Molecolare (M.I., A.L.C., S.M., E.D.V., G.R.), Endocrinologia ed Oncologia Molecolare e Clinica (F.M., G.F., M.V.), and Scienze Biomorfologiche e Funzionali (G.T.), and Unit of Endocrine and General Surgery (L.A.M.), Università Federico II, 80131 Naples, Italy; and Institute of Endocrinologia ed Oncologia Sperimentale “G. Salvatore” (G.R.), Consiglio Nazionale delle Ricerche, 80131 Naples, Italy
منابع مشابه
Calcium/calmodulin-dependent protein kinase II binds to Raf-1 and modulates integrin-stimulated ERK activation.
Integrin activation generates different signalings in a cell type-dependent manner and stimulates cell proliferation through the Ras/Raf-1/Mek/Erk pathway. In this study, we demonstrate that integrin stimulation by fibronectin (FN), besides activating the Ras/Erk pathway, generates an auxiliary calcium signal that activates calmodulin and the Ca2+/calmodulin-dependent protein kinase II (CaMKII)...
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